The effects of polar excipients transcutol and dexpanthenol on molecular mobility, permeability, and electrical impedance of the skin barrier. Print Share. Results Diethylene glycol monoethyl ether when used in a 99.9+% pure pharmaceutical grade is safe and well tolerated. Ethyl Diglycol is used as a flow and gloss promoter in paint industries. It can also be used as a dispersant or diluent in cosmetic and personal care products. 2-Methoxyethanol is also a perfume fixative. A literature search was conducted from the year prior to the OECD SIAM Footnote 22 (i.e., October 2004 to April 2016), and no health effects studies that would result in critical effect levels lower than those identified by OECD (2007) were identified. Up to half of the applied solvent crosses the skin’s barrier and becomes systemic. Excellent separation in 23 min with capillary AT TM-AQUAWAX column. NIH Conclusions: Epub 2017 Nov 6. ETHOXYDIGLYCOL ETHOXYDIGLYCOL is classified as : Humectant; Solvent; Perfuming; CAS Number: 111-90-0 EINECS/ELINCS No: 203-919-7 COSING REF No: 33802 Chem/IUPAC Name: 2-(2-Ethoxyethoxy)ethanol; Carbitol; Diethylene glycol monoethyl ether; … US $3.50-$4.10 / Kilogram. Diethylenglycolmonoethylether ist eine farblose Flüssigkeit mit süß-muffig bis fruchtigem Geruch. 2019 Nov 9;11(11):594. doi: 10.3390/pharmaceutics11110594. Diese werden vorwiegend als Lösungsmittel, vor allem in Anstrichmitteln, sowie als Basis für Epoxydharze verwendet. 2014 Oct;72:40-50. doi: 10.1016/j.fct.2014.06.028. Application of diethylene glycol monoethyl ether in solubilization of poorly water-soluble drugs. Diethylene glycol monoethyl ether (DEGEE) is produced via the O-alkylation of ethanol with two ethylene oxide units, followed by distillation. Synonyms. diethylene glycol monoethyl ether was done by a member state (France). Gewinnung und Darstellung. Glycol ethers Last updated September 26, 2020. It is used primarily as a coalescing aid in latex paints and as a solvent in printing inks. Transcutol® or diethylene glycol monoethyl ether is a liquid which has a long history of use in cosmetic and over-the-counter topically applied products. Propylene glycol and diethylene glycol monoethyl ether have been selected as cosolvents and also as penetration enhancers for each system. The extendability of solution has also increased. Pharmaceutics. Journal of Drug Delivery Science and Technology. Transcutol® or diethylene glycol monoethyl ether is a liquid which has a long history of use in cosmetic and over-the-counter topically applied products. Background: It is a solvent for dyes, nitrocellulose, paints, inks, and resins. Transcutol® (Diethylene glycol monoethyl ether, DEGEE), CAS # 111-90-0, is commonly used as a vehicle in the formulation or manufacturing process of pharmaceuticals, cosmetics, and food additives. Diethylene Glycol M-Ethylether; Diethylene Glycol Monoethyl Ether; Trivalin SF; Unilene DEG400; Carbitol-, APV; Diethylene Glycol ethyl ether; 3,6-Dioxa-1-Octano Storage. Diethylene glycol monoethyl ether (DEGEE) is widely used as a solubilizer in cosmetics as well as in oral, topical, transdermal and injectable pharmaceutical formulations. Dermatologists are already treating patients that apply products containing 5–40% of this solvent multiple times each day. The solvents diethylene glycol monomethyl ether, diethylene glycol monoethyl ether and diethylene glycol mono-n-butyl ether serve as diluents in hydraulic brake fluids. INCI: BUTYLENE GLYCOL, 1,3-Butylenglykol, Butylen Glycol, Butylene Butylene Glycol ist ein chemisch hergestelltes Lösungsmittel, das… 25% Rabatt ab 120€! | This paper presents unpublished nonclinical safety data using a form of DEGEE which includes a significantly decreased level of impurities, specifically ethylene glycol and diethylene glycol. Diethyl Glycol Monoethyl Ether - CAS No. Transcutol® (Diethylene glycol monoethyl ether, DEGEE), CAS # 111-90-0, is commonly used as a vehicle in the formulation or manufacturing process of pharmaceuticals, cosmetics, and food additives. The solvent diethylene glycol monoethyl ether (DEGEE) is currently used in over 500 cosmetic products and has enabled the formulation of a topical 5% dapsone gel for the treatment of acne. Glycol ethers are a group of solvents based on alkyl ethers of ethylene glycol or propylene glycol commonly used in paints and cleaners. 1) is a colorless liquid with a molecular weight of 137.17 g/mol and a density of 0.989 g/mL. It is produced by the ethoxylation of ethanol.. USA.gov. Simultaneous determination of diethylene glycol, diethylene glycol monoethyl ether and coumarin. Methods To critically review technical and patent literature that provides insight into this novel solvent. Ethoxydiglycol can be classified as a glycol. The risk assessment is based mainly on open scientific literature and on skin absorptions studies done by Industry. Diethylene Glycol n-Butyl Ether YES <0.028 0.004 210/99 30.0 16.0 7.0 10.6 ∞ Non-food use Butyl CELLOSOLVE™ Solvent (BuCs) Ethylene Glycol n-Butyl Ether NO 0.66 0.079 149/65 27.4 16.0 7.6 12.3 ∞ 40 CFR 180.940* Applications Used as solvent and coupling agents in household and industrial cleaners. No additives studied were found in the samples analysed. Aims: Am J Clin Dermatol. Quality Assessment of API in Semisolid Topical Drug Products. It is anticipated that this common cosmetic ingredient will be a component in numerous future prescription topical products approved for the US market. It is an excipient used as a solubilising agent and an absorption enhancer. Background The solvent diethylene glycol monoethyl ether (DEGEE) is currently used in over 500 cosmetic products and has enabled the formulation of a topical 5% dapsone gel for the treatment of acne. Diethylene glycol monoethyl ether (DGEE; see Fig. Clipboard, Search History, and several other advanced features are temporarily unavailable. The risk assessment led the member state to put some restrictions on the use this substance. | The purpose of this document is to reassess the exemptions from the requirement of a tolerance for residues of these chemicals when used as inert ingredients in pesticide formulations as required under the Food Quality Protection Act (FQPA). Enhancing oral absorption of poorly water-soluble herb ( Other veterinary products not covered by the application containing diethylene glycol monoethyl ether are topical formulations for use in all species (at concentrations up to 40%) and oral formulations (at concentrations up to 30%). Epub 2020 Feb 1. Moreno E, Calvo A, Schwartz J, Navarro-Blasco I, González-Peñas E, Sanmartín C, Irache JM, Espuelas S. Pharmaceutics. Use: Eastman™ DE Solvent (Diethylene Glycol Monoethyl Ether) is a very polar, slow evaporating, water miscible solvent with a low odor. AbstractBackgroundDiethylene glycol monoethyl ether (DEGEE) is widely used as a solubilizer in cosmetics as well as in oral, topical, transdermal and injectable pharmaceutical formulations. For certain drug actives, this solvent provides for an intracutaneous depot. Passive delivery of protein drugs through transdermal route. Diethylene glycol monoethyl ether when used in a 99.9+% pure pharmaceutical grade is safe and well tolerated. Pireddu R, Sinico C, Ennas G, Schlich M, Valenti D, Murgia S, Marongiu F, Fadda AM, Lai F. Colloids Surf B Biointerfaces. Artificial Cells, Nanomedicine, and Biotechnology. DRBOB@VERDIENT.BIZ Member. OK. Home INCI Directory Print Share. 2-(2-Ethoxyethoxy)ethanol, also known under many trade names, is the organic compound with the formula CH 3 CH 2 OCH 2 CH 2 OCH 2 CH 2 OH. Buy Glycol Ether DB For $43 | Buy Diethylene Glycol Online | SDS | Shipped FedEx | Diethylene Glycol Monoethyl Ether | High Boiling Point Glycol Ether | Purified | CAS 111-90-0 | Formula C6H14O3 | 2-(2-Ethoxyethoxy)ethanol | Solvent & Coupling Agent | Glycol Ethers are a group of solvents based on alkyl ethers of ethylene glycol or propylene glycol commonly used in paints and cleaners. The substance is also used in human medicines as well as in cosmetics. It has a long history of safe use in food and personal-care products, and is used as an effective strong solubilizer in oral, topical, transdermal, and injectable human and veterinary pharmaceutical products. 2-Phenoxyethanol is a fixative for perfumes, cosmetics and soaps, a textile dye carrier and a solvent for cleaners, inks, germicides and pharmaceuticals. Diethylene glycol monoethyl ether is asolubilising agent and an absorption enhancer used in veterinary medicine. Evaluation of Skin Permeation and Retention of Topical Dapsone in Murine Cutaneous Leishmaniasis Lesions. Enter your email address below and we will send you your username, If the address matches an existing account you will receive an email with instructions to retrieve your username, By continuing to browse this site, you agree to its use of cookies as described in our, I have read and accept the Wiley Online Library Terms and Conditions of Use. Diethyl Glycol Monoethyl Ether - CAS No. HHS Used in cosmetic and personal care products as well. Kaempferia parviflora Formulation and evaluation of self-nanoemulsifying drug delivery system of brigatinib: Improvement of solubility, in vitro release, ex-vivo permeation and anticancer activity. code: blackweek25; 15% Rabatt (ohne MBW)! 1/6. See EPA’s About PDF page to learn more. Product Description: Eastman DE Acetate (diethylene glycol monoethyl ether acetate) is a colorless liquid, soluble in water and miscible in most organic solvents. Flash point near 190°F. Glycol Ethyl Methyl CAS 1002-67-1 Inkjet Grade DGMEE / Diethylene Glycol Ethyl Methyl Ether. BACKGROUND: The solvent diethylene glycol monoethyl ether (DEGEE) is currently used in over 500 cosmetic products and has enabled the formulation of a topical 5% dapsone gel for the treatment of acne. Journal of Colloid and Interface Science. Concern Use the link below to share a full-text version of this article with your friends and colleagues. A review of the nonclinical safety of Transcutol®, a highly purified form of diethylene glycol monoethyl ether (DEGEE) used as a pharmaceutical excipient, https://doi.org/10.1111/j.1473-2165.2011.00590.x. This paper presents unpublished nonclinical safety data using a form of DEGEE which includes a signific … It is also used in cosmetic & perfumary industry as a solvent. This solvent has not demonstrated any inherent antimicrobial properties but was found to be mildly inhibitory toward Propionibacterium acnes. Dermatologists are already treating patients that apply products containing 5-40% of this solvent multiple times each day. 2-(2-Ethoxyethoxy)ethanol, also known under many trade names, is the organic compound with the formula CH 3 CH 2 OCH 2 CH 2 OCH 2 CH 2 OH. It is anticipated that this common cosmetic ingredient will be a component in numerous future prescription topical products approved for the US market. [125] compared two columns (SPB-35 column vs. ATTM AQUAWAX column) for the separation of diethylene glycol, diethylene glycol monoethyl ether, coumarin and caffeine in food. Please enable it to take advantage of the complete set of features! Expert Opin Pharmacother. Ethoxydiglycol, also known as diethylene glycol monoethyl ether or DEGEE, is produced by the ethoxylation of ethanol. It is a colorless liquid. glycol monomethyl ether, diethylene glycol monoethyl ether, and diethylene glycol monobutyl ether. It has a long history of safe use in food and personal-care products, and is used as an effective strong solubilizer in oral, topical, transdermal, and injectable human and veterinary pharmaceutical products. Rahim et al. Transcutol® (Diethylene glycol monoethyl ether, DEGEE), CAS # 111-90-0, is commonly used as a vehicle in the formulation or manufacturing process of pharmaceuticals, cosmetics, and food additives. It is a popular solvent for commercial applications. The purpose of this document is to reassess the exemptions from the requirement of a tolerance for residues of these chemicals when used as inert ingredients in pesticide formulations as required under the Food Quality Protection Act (FQPA). Epub 2014 Jul 9. This paper presents unpublished nonclinical safety data using a form of DEGEE which includes a significantly decreased level of impurities, specifically ethylene glycol and diethylene glycol. The microemulsion prepared … It has a long history of safe use in food and personal-care products, and is used as an effective strong solubilizer in oral, topical, transdermal, and injectable human and veterinary pharmaceutical products. 2018 Feb 1;162:8-15. doi: 10.1016/j.colsurfb.2017.11.012. It is a colorless liquid. It is an excipient to be used in an injectable product (containing a non-steroidal anti-inflammatory agent) for cattle and pigs at a concentration of 30%. This substance is used in the following products: coating products, fillers, putties, plasters, modelling clay, perfumes and fragrances, cosmetics and personal care products, adhesives and sealants, washing & cleaning products, biocides (e.g. . It is anticipated that this common cosmetic ingredient will be a component in numerous future prescription topical products approved for the US market. COVID-19 is an emerging, rapidly evolving situation. It is used primarily as a coalescing aid in latex paints and as a solvent in printing inks. Order) CN Anhui Sincerely Titanium Industry Co., Ltd. 9 YRS. The Role of Microstructure in Topical Drug Product Development. Please check your email for instructions on resetting your password. Transcutol® (Diethylene glycol monoethyl ether, DEGEE), CAS # 111-90-0, is commonly used as a vehicle in the formulation or manufacturing process of pharmaceuticals, cosmetics, and food additives. Its ability to modify the skin delivery of actives it is formulated with (or formulation components that are applied just shortly before or after) make it important for dermatologists to have an understanding of this emerging solvent. If you do not receive an email within 10 minutes, your email address may not be registered, Butylene Glycol, Hexylene Glycol, Ethoxydiglycol and Dipropylene Glycol are clear, practically colorless, liquids. NLM Transcutol® (Diethylene Glycol Monoethyl Ether): A Potential Penetration Enhancer. J Clin Aesthet Dermatol. 190 Kilograms (Min. For certain drug actives, this solvent provides for an intracutaneous depot. It is produced by the ethoxylation of ethanol.. Transcutol® has been applied in several commercial preparations and is used in many studies as the main ingredient of formulations. 2-Phenoxyethanol is a fixative for perfumes, cosmetics and soaps, a textile dye carrier and a solvent for cleaners, inks, germicides and pharmaceuticals. Due to the unavailability of detailed toxicological studies on DEGEE, the Scientific Committee on Consumer Products (SCCP) found its toxicological reports to be unsatisfactory, comprising only summaries. Dapsone 5% gel: a review of its efficacy and safety in the treatment of acne vulgaris. Background: Diethylene glycol monoethyl ether (DEGEE) is produced via the O-alkylation of ethanol with two ethylene oxide units, followed by distillation. Diethylene glycol monoethyl ether (DEGEE) is produced via the O-alkylation of ethanol with two ethylene oxide units, followed by distillation. To provide dermatologists a review of this solvent's safety and tolerance in addition to describing how it interacts with the stratum corneum, sebum, and resident microflora. 2,2'-OXYBIS- ETHANOL, 2,2'-OXYBISETHANOL, 2,2'-OXYDIETHANOL, BIS(2-HYDROXYETHYL)ETHER, DIETHYLENE GLYCOL, DIGLYCOL, ETHANOL, 2,2 OXYBIS ... use, concentration, or manufacturing restrictions - Japan - prohibited for use in some types of cosmetics: Japan's Standards for Cosmetics: Occupational hazards. Skin Penetration and Permeation Properties of Transcutol®-Neat or Diluted Mixtures. It is anticipated that this common cosmetic ingredient will be a component in numerous future prescription topical products approved for the US market. Diethylene glycol monoethyl ether (DEGEE) OECD (2007) and SCCP (2006a) summarize the health effects literature related to DEGEE. Ethyl Diglycol is used in the production & formulation of pesticides & wood preservaties. Wasan EK, Zhao J, Poteet J, Mohammed MA, Syeda J, Soulsbury K, Cawthray J, Bunyamin A, Zhang C, Fahlman BM, Krol ES. Use: Eastman™ DE Solvent (Diethylene Glycol Monoethyl Ether) is a very polar, slow evaporating, water miscible solvent with a low odor. CAS Number: 111-90-0 EINECS/ELINCS No: 203-919-7 COSING REF No: 33802 Chem/IUPAC Name: 2-(2-Ethoxyethoxy)ethanol; Carbitol; Diethylene glycol monoethyl ether; DEGEE Diethylene glycol monoethyl ether (DEGEE) is widely used as a solubilizer in cosmetics as well as in oral, topical, transdermal and injectable pharmaceutical formulations. | Conclusions This safe, well‐tolerated solvent is already used in many cosmetics and will become an ingredient in an increasing number of prescription products. It is an active solvent for cellulose acetate butyrate, nitrocellulose, epoxy resins, and other coating materials. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Methods: What options do I have to mask the odor, or are there replacements for ethoxydiglycol? Keep away from sources of ignition. Ethyl Ethyl BMK Powder Ethyl 2-phenylacetoacetate CAS 5413-05-8 Top Quality. Eastman DE Solvent (Diethylene Glycol Monoethyl Ether) is a very polar, slow evaporating, water miscible solvent with a low odor. Would you like email updates of new search results? Commonly used in paints. Diethylene glycol monoethyl ether belongs to the family of glycol ethers. The full text of this article hosted at iucr.org is unavailable due to technical difficulties. Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement. Applications. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Synonyms. Up to half of the applied solvent crosses the skin's barrier and becomes systemic. Glycol ethers are a group of solvents based on alkyl ethers of ethylene glycol or propylene glycol commonly used in paints and cleaners. Due to the unavailability of detailed toxicological studies on DEGEE, the Scientific Committee on Consumer Products (SCCP) found its toxicological reports to be unsatisfactory, comprising only summaries. Diethylene Glycol Monoethyl Ether has low setting point and low viscocity at low temperature so it is used in manufacturing Brake Fluid. It is anticipated that this common cosmetic ingredient will be a component in numerous future prescription topical products approved for the US market. ) extract using self-nanoemulsifying formulation and you may need to create a new Wiley Online Library account. and perfumes and cosmetics. Diethylene Glycol Monoethyl Ether is also used a solubilizer in drilling and cutting coolants. Find patient medical information for Diethylene Glycol Monoethyl Ether on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Eigenschaften. Development of a UV-Stabilized Topical Formulation of Nifedipine for the Treatment of Raynaud Phenomenon and Chilblains. Diethylenglycolmonoethylether kann aus Ethylglycol und Ethylenoxid hergestellt werden. use HEXYL CARBITOL™Diethylene Glycol Solvent Hexyl Ether YES 0.001 <0.01 275/135 29.2 16.0 6.0 10.0 2.0 Propyl CELLOSOLVE™ Solvent Ethylene Glycol Propyl Ether NO 1.6 0.2 124/51 26.3 16.1 8.0 13.1 ∞ DOWANOL™ DiEPh Solvent Diethylene Glycol Phenyl Ether It is an active solvent for cellulose acetate butyrate, nitrocellulose, epoxy resins, and other coating materials. 2009;10(4):221-7. doi: 10.2165/00128071-200910040-00002. Used to make soaps, dyes, and other chemicals. Skin Penetration and Permeation Properties of Transcutol®—Neat or Diluted Mixtures. 2019 Nov 13;11(11):607. doi: 10.3390/pharmaceutics11110607. Food Chem Toxicol. Pharmaceutical Development and Technology. 111-90-0; Diethyl Glycol Monomethyl Ether - CAS No. August 2017 in Formulating. glycol monomethyl ether, diethylene glycol monoethyl ether, and diethylene glycol monobutyl ether. The substance is known to be used in oral, topical and injectable formulation s in several animal species as well as in human medicines and in cosmetics. US $40.00-$50.00 / Kilogram. Diethylene glycol is metabolized in the liver by two consecutive oxidized form of nicotinamide adenine dinucleotide-dependent reactions. Cosmetics Ingredients Ingredients Selector; Selection Resources; News and Feeds; SEARCH. Epub 2018 Nov 12. Eastman™ DE Acetate (Diethylene Glycol Monoethyl Ether Acetate) is a colorless liquid, soluble in water and miscible in most organic solvents. Background: Diethylene glycol monoethyl ether (DEGEE) is widely used as a solubilizer in cosmetics as well as in oral, topical, transdermal and injectable pharmaceutical formulations. Diethylene glycol monoethyl ether (DGEE; see Fig. 5.0 (1) "Customer service" "Great company" Contact Supplier. Tagged: odor; glycol ethers; Comments. » Diethylene Glycol Monoethyl Ether contains not less than 99.0 percent and not more than 101.0 percent of C 6 H 14 O 3.It is produced by condensation of ethylene oxide and alcohol, followed by distillation. This site needs JavaScript to work properly. The solvents diethylene glycol monomethyl ether, diethylene glycol monoethyl ether and diethylene glycol mono-n-butyl ether serve as diluents in hydraulic brake fluids. August 2017. Butylene Glycol ist ein Lösungsmittel, das feuchtigkeitsbindend wirkt. Number of times cited according to CrossRef: Microemulsion composed of combination of skin beneficial oils as vehicle: Development of resveratrol-loaded microemulsion based formulations for skin care applications. AAPS PharmSciTech. In cosmetics and personal care products, these ingredients are used in the formulation of hair and bath products, eye and facial makeup, fragrances, personal cleanliness products, and shaving and skin care products. 92.9%. Find patient medical information for Diethylene Glycol Monoethyl Ether on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Its ability to modify the skin delivery of actives it is formulated with (or formulation components that are applied just shortly before or after) make it important for dermatologists to have an understanding of this emerging solvent. Some commonly used glycol ethers are listed on page 2, along with their abbreviations and chemical names, ... ethanol diethylene glycol monoethyl ether ethoxyethoxy)ethanol diethylene glycol monobutyl ether ethanol diethylene glycol dimethyl ether Diethylene glycol monoethyl ether: DEGEE: 112-07-2: Ethanol, 2-butoxy-, acetate: Ethylene glycol monobutyl ether acetate: EGBEA: 112-34-5: Ethanol, 2-(2-butoxyethoxy)- Diethylene glycol monobutyl ether: DEGBE: a The CAS RN is the property of the American Chemical Society and any use or redistribution, except as required in supporting regulatory requirements and/or for reports to the … It is used mainly as a solvent in the manufacture of cellulose esters, Topical Corticosteroid Therapy for Psoriasis-A Review of Clobetasol Propionate 0.025% Cream and the Clinical Relevance of Penetration Modification. 111-90-0; Diethyl Glycol Monomethyl Ether - CAS No. Due to its low volatility property it is used in Indian & ink ball point pastes. 112-34-5 You may need a PDF reader to view some of the files on this page. In cosmetics and personal care products, these ingredients are used in the formulation of hair and bath products, eye and facial makeup, fragrances, personal cleanliness products, and shaving and skin care products. Learn about our remote access options. Due to the unavailability of detailed toxicological studies on DEGEE, the Scientific Committee on Consumer Products (SCCP) found its toxicological reports to be unsatisfactory, comprising only summaries. Diethylene Glycol is an aliphatic diol. The effect of diethylene glycol monoethyl ether on skin penetration ability of diclofenac acid nanosuspensions. Emerging Technologies to Target Drug Delivery to the Skin – the Role of Crystals and Carrier-Based Systems in the Case Study of Dapsone. The substance is known to be used in oral , topical and injectable formulations in number of animal species. Background The solvent diethylene glycol monoethyl ether (DEGEE) is currently used in over 500 cosmetic products and has enabled the formulation of a topical 5% dapsone gel for the treatment of acne. A second opinion (SCCP/1200/08) on Diethylene glycol monoethyl ether (DEGEE) for its use as solvent in hair dye formulations was adopted on 16 December 2008 with the conclusion that: "The SCCP is of the opinion that the use of diethylene glycol monoethyl ether (DEGEE) as a It is an active solvent for cellulose acetate butyrate, nitrocellulose, epoxy resins, and other coating materials. Impact of the chemical and physical stability of ketoprofen compounded in various pharmaceutical bases on its topical and transdermal delivery. An evaluation of dapsone gel 5% in the treatment of acne vulgaris. * Used as a solvent and carrier in skin care products * Also known as Diethylene Glycol Monoethyl Ether Functions: According to RealSelf.com, Ethoxydiglycol is a clear, practically colorless, liquids used in cosmetics and personal care products.It is a solvent used to thin out products and decrease viscosity.